Saturday, January 19, 2008

NSAIDs and Alpha-1 Antitrypsin Deficiency

Hmmm! I guess the children's ibuprofen in use at my house should be discontinued. Interesting, and I'm amazed this isn't more well known within the Alpha-1 community. Obviously, this hasn't been tested on humans, but animal models are really quite interesting and can show causal relationships.

Non-Steroidal Anti-Inflammatory Drug Increases Liver Damage In Mice Carrying Mutant Human Gene

Alpha-1-antitrypsin deficiency isn't a term that rolls right off the tongue. But people diagnosed with this genetic disorder learn its potential effects well. They know they shouldn't smoke or be around smokers because they are at increased risk for developing emphysema at a young age. In addition, some patients with alpha-1-antitrypsin (AT) deficiency can develop serious liver disease. But predicting which of them are at risk for liver disease is not yet possible.

Now research performed at Washington University School of Medicine in St. Louis sheds light on the mechanisms that contribute to liver disease in alpha-1-AT deficiency patients. Using an experimental mouse model of the disorder, the researchers investigated the effects of a non-steroidal anti-inflammatory drug (NSAID) on liver injury. An estimated 15 to 20 million people in the United States take NSAIDs like ibuprofen and naproxen on a long-term basis. Read the rest at:

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